CHANGES IN FILIPIN-STEROL BINDING IN THE RAT CINGULATE CORTEX AFTER THE ADMINISTRATION OF ANTIDEPRESSANT DRUGS - A FREEZE-FRACTURE STUDY

被引：7

作者：

BAL, A

BIRD, MM

机构：

[1] QUEEN MARY & WESTFIELD COLL,FAC BASIC MED SCI,DEPT ANAT,LONDON,ENGLAND

[2] POLISH ACAD SCI,INST PHARMACOL,PL-30060 KRAKOW,POLAND

来源：

BRAIN RESEARCH | 1991年 / 550卷 / 01期

基金：

英国惠康基金;

关键词：

CINGULATE CORTEX; ANTIDEPRESSANT; FILIPIN-STEROL COMPLEX; FREEZE-FRACTURE;

D O I：

10.1016/0006-8993(91)90419-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The amount of cholesterol in cell membranes of cingulate cortex nerve cells from rats treated with Imipramine (tricyclic antidepressant drug) or mianserin (non-trycyclic antidepressant) was investigated using filipin-sterol binding and freeze-fracture. The number of filipin-sterol complexes decreased within membranes of neurons from cingulate cortex chronically treated with imipramine or mianserin. These results suggest that the decreased content of cholesterol causes the cell membrane to become more fluid. This increased fluidity of the cell membrane may play an important role in regulating the interaction of transmitters and drugs with their membrane receptors.

引用

页码：147 / 151

页数：5

共 20 条

[1] TRICYCLIC ANTI-DEPRESSANT DESIPRAMINE INDUCES STEREOSPECIFIC OPIATE BINDING AND LIPID MODIFICATIONS IN RAT GLIOMA C6-CELLS [J].