INVITRO EVALUATION OF MUCOADHESIVE PROPERTIES OF CHITOSAN AND SOME OTHER NATURAL POLYMERS

被引：837

作者：

LEHR, CM ^{[1
]}

BOUWSTRA, JA ^{[1
]}

SCHACHT, EH ^{[1
]}

JUNGINGER, HE ^{[1
]}

机构：

[1] STATE UNIV GHENT,DEPT POLYMER CHEM,ORGAN CHEM LAB,B-9000 GHENT,BELGIUM

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 78卷 / 01期

关键词：

CHITOSAN; DETACHMENT FORCE; HYDROGEL; MUCOADHESION; POLYCARBOPHIL; WASH-OFF TEST;

D O I：

10.1016/0378-5173(92)90353-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A number of natural or partially modified polymers was screened for mucoadhesive properties by routinely measuring the force of detachment for swollen polymer films from pig intestinal mucosa in a saline medium. Surprisingly, hydroxypropyl- and carboxymethylcellulose showed almost no mucoadhesion, whereas the cationic polymer chitosan was fairly mucoadhesive in comparison to Polycarbophil as a reference substance. It is suggested that a strict difference be made between mucoadhesion of dry polymers on a wet tissue in air, and mucoadhesion of a swollen hydrogel in the presence of a third liquid phase. Cationic polymers should be further investigated with respect to possibly improved mucoadhesive properties in a neutral or slightly alkaline environment.

引用

页码：43 / 48

页数：6

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