THE HUMORAL IMMUNE-RESPONSE TO HEAT-SHOCK PROTEINS

被引：23

作者：

MOLLENHAUER, J ^{[1
]}

SCHULMEISTER, A ^{[1
]}

机构：

[1] RUSH MED SCH, DEPT BIOCHEM, CHICAGO, IL 60612 USA

来源：

EXPERIENTIA | 1992年 / 48卷 / 07期

关键词：

HSP65; HSP60; AUTOIMMUNITY; RHEUMATOID ARTHRITIS; ADJUVANT ARTHRITIS; MYCOBACTERIA;

D O I：

10.1007/BF02118310

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Humoral immune reactions to heat shock proteins (hsp) from microorganisms are one aspect of microbial infections in humans. The production of antibodies which are specific to epitopes present on procaryotic hsp leads also to the appearance of cross-reactive serum antibodies in the host organism that react with human hsp. This article discusses the consequences of such autoreactive antibodies for the host in context with the development of immune tolerance and autoimmune diseases, especially rheumatoid arthritis (RA), and in experimental animal models for arthritis such as adjuvant arthritis in rats. On the basis of epitope cross-reactivity between hsp and other host proteins, a hypothesis is presented for the development of autoimmune disease following the production of hsp-specific antibodies.

引用

页码：644 / 649

页数：6

共 55 条

[1] CROSS-REACTIVITY AND SEQUENCE HOMOLOGY BETWEEN THE 65-KILODALTON MYCOBACTERIAL HEAT-SHOCK PROTEIN AND HUMAN LACTOFERRIN, TRANSFERRIN, AND DR-BETA SUBSETS OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II MOLECULES [J].