LIVER MICROSOMAL ALKOXYPHENOXAZONE O-DEALKYLASES OF WHITE LEGHORN CHICKENS - RESPONSE TO MIXED-FUNCTION OXIDASE INDUCERS

被引：3

作者：

BANTON, MI

WINSTON, GW

FLORY, W

机构：

[1] LOUISIANA STATE UNIV,LOUISIANA VET MED DIAGNOST LAB,BATON ROUGE,LA 70803

[2] LOUISIANA STATE UNIV,DEPT BIOCHEM,BATON ROUGE,LA 70803

[3] LOUISIANA STATE UNIV,INST ENVIRONM STUDIES,BATON ROUGE,LA 70803

[4] TEXAS VET MED DIAGNOST LABS,COLL STN,TX 77841

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1992年 / 102卷 / 03期

关键词：

D O I：

10.1016/0742-8413(92)90142-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The cytochrome P-450 substrates, methoxy-, ethoxy-, pentoxy- and benzyloxyphenoxazone were investigated in liver microsomes of phenobarbital- and beta-napththoflavone-induced White Leghorn chickens and compared to the rat mammalian model. 2. Thirty-two-fold increases in benzyloxyphenoxazone O-dealkylase and 27-fold increases in ethoxyphenoxazone O-dealkylase activities were observed in beta-naphthoflavone-treated chickens compared to only an 18-fold increase in ethoxyphenoxazone O-dealkylase activity in beta-naphthoflavone-treated rats. 3. Decreases in pentoxy- and benzyloxyphenoxazone O-dealkylase activities were observed in phenobarbital-treated chickens in contrast to increases of 197-fold in pentoxy- and 98-fold in benzyloxyphenoxazone O-dealkylases in the phenobarbital-treated rats.

引用

页码：455 / 458

页数：4

共 15 条

[1] METABOLISM OF ALKOXYPHENOXAZONES BY CHANNEL CATFISH LIVER-MICROSOMES - EFFECTS OF PHENOBARBITAL, AROCLOR-1254 AND 3-METHYLCHOLANTHRENE [J].