CELLULAR-LOCALIZATION OF A METABOTROPIC GLUTAMATE RECEPTOR IN RAT-BRAIN

被引：483

作者：

MARTIN, LJ

BLACKSTONE, CD

HUGANIR, RL

PRICE, DL

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,NEUROPATHOL LAB,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205

[4] JOHNS HOPKINS UNIV,SCH MED,HOWARD HUGHES MED INST,BALTIMORE,MD 21205

来源：

NEURON | 1992年 / 9卷 / 02期

关键词：

D O I：

10.1016/0896-6273(92)90165-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In rat brain, the cellular localization of a phosphoinositide-linked metabotropic glutamate receptor(mGluR1-alpha) was demonstrated using antibodies that recognize the C-terminus of the receptor. mGluR1-alpha, a 142 kd protein, is enriched within the olfactory bulb, stratum oriens of CA1 and polymorph layer of dentate gyrus in hippocampus, globus pallidus, thalamus, substantia nigra, superior colliculus, and cerebellum. Lower levels of mGluR1-alpha are present within neocortex, striatum, amygdala, hypothalamus, and medulla. Dendrites, spines, and neuronal cell bodies contain mGluR1-alpha. mGluR1-alpha is not detectable in presynaptic terminals. mGluR1-alpha and ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor subunits show differential distributions, but in Purkinje cells, mGluR1-alpha and specific AMPA receptor subunits colocalize. The postsynaptic distribution of mGluR1-alpha is consistent with postulated physiological roles of this subtype of glutamate receptor.

引用

页码：259 / 270

页数：12

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