IN-VIVO RELEASE OF DOPAMINE FROM RAT STRIATUM, SUBSTANTIA-NIGRA AND PREFRONTAL CORTEX - DIFFERENTIAL MODULATION BY BACLOFEN

被引：40

作者：

SANTIAGO, M ^{[1
]}

MACHADO, A ^{[1
]}

CANO, J ^{[1
]}

机构：

[1] FAC FARM SEVILLA,DEPT BIOQUIM,E-41012 SEVILLE,SPAIN

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1993年 / 109卷 / 03期

关键词：

DOPAMINE; MICRODIALYSIS; (+/-)-BACLOFEN; GABA(B) RECEPTOR AGONIST; STRIATUM; SUBSTANTIA-NIGRA; PREFRONTAL CORTEX;

D O I：

10.1111/j.1476-5381.1993.tb13647.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The effect of baclofen, a GABA(B) receptor agonist, on the release of dopamine from the striatum (ST), substantia nigra (SN) and prefrontal cortex (PFC) of the rat was examined by intracerebral microdialysis. 2 Perfusion of baclofen 50 mum did not affect the striatal release of dopamine. However, dopamine release was markedly reduced in the SN and PFC. 3 3,4-Dihydroxyphenylacetic acid and homovanillic acid output increased in the ST and decreased in the SN and PFC when baclofen was perfused through the microdialysis probe. 5-Hydroxyindoleacetic acid levels were not affected in any experimental condition by baclofen perfusion. 4 The results suggest that GABA(B) receptors modulate the release of dopamine in the SN and PFC, but do not affect the striatal release of dopamine, which indicates that the role of GABA receptor activation is different in the dopaminergic terminals of the ST and PFC.

引用

页码：814 / 818

页数：5

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[1] DIFFERENTIAL EFFECT OF STRESS ON INVIVO DOPAMINE RELEASE IN STRIATUM, NUCLEUS ACCUMBENS, AND MEDIAL FRONTAL-CORTEX [J].