SUNLIGHT-INDUCED MUTAGENICITY OF A COMMON SUNSCREEN INGREDIENT

被引:76
作者
KNOWLAND, J
MCKENZIE, EA
MCHUGH, PJ
CRIDLAND, NA
机构
[1] Department of Biochemistry, Oxford, OX1 3QU, South Parks Road
来源
FEBS LETTERS | 1993年 / 324卷 / 03期
基金
英国惠康基金;
关键词
SUNSCREEN; PADIMATE-O; OCTYL DIMETHYL PABA; PARSOL-1789; MUTAGENESIS; CARCINOGENESIS;
D O I
10.1016/0014-5793(93)80141-G
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have tested the mutagenicity of a UV-B sunscreen ingredient called Padimate-O or Octyl dimethyl PABA, which, chemically speaking, is identical to an industrial chemical that generates free radicals when illuminated. It is harmless in the dark but mutagenic in sunlight, attacking DNA directly. A commercial sunscreen containing Padimate-O behaves in the same way. UV-A in sunlight also excites Padimate-O, although less than UV-B. Some related compounds, including a known carcinogen, behave similarly. As mutagens may be carcinogenic, our results suggest that some sunscreens could, while preventing sunburn, contribute to sunlight-related cancers.
引用
收藏
页码:309 / 313
页数:5
相关论文
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