TETRACYCLINE-INDUCED BILE-DUCT PAUCITY AND PROLONGED CHOLESTASIS

被引：35

作者：

HUNT, CM ^{[1
]}

WASHINGTON, K ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT PATHOL,DURHAM,NC 27710

来源：

GASTROENTEROLOGY | 1994年 / 107卷 / 06期

关键词：

D O I：

10.1016/0016-5085(94)90830-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Acute self-limited liver disease has been associated with tetracycline use. However, severe prolonged cholestatic hepatitis and bile duct paucity have not been previously attributed to tetracyclines. Hepatitis, characterized by prolonged jaundice, severe pruritus, and moderate increased transaminase values, occurred within 2 months of ingesting tetracyclines in two female patients. Serum bilirubin levels normalized 12 and 34 months after tetracycline ingestion. Liver histology revealed bile duct paucity, severe cholestasis, and minimal necrosis and inflammation. Tetracyclines may infrequently induce bile duct paucity and prolonged, severe, and reversible cholestasis.

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页码：1844 / 1847

页数：4

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