SPECIFIC IGE ANTIBODIES TO PLATINUM SALTS IN SENSITIZED WORKERS

被引：132

作者：

CROMWELL, O

PEPYS, J

PARISH, WE

HUGHES, EG

机构：

[1] BROMPTON HOSP,INST CARDIOTHORAC SURG,DEPT CLIN IMMUNOL,LONDON SW3 6HP,ENGLAND

[2] UNILEVER RES LAB,SHARNBROOK MK44 1LQ,BEDFORDSHIRE,ENGLAND

[3] JOHNSON MATTHEY & CO LTD,LONDON,ENGLAND

来源：

CLINICAL ALLERGY | 1979年 / 9卷 / 02期

关键词：

D O I：

10.1111/j.1365-2222.1979.tb01529.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

A RAST has been developed for the measurement of IgE antibodies specific to platinum chloride complexes in sensitized workers. Human serum albumin covalently linked to Sepharose beads by the cyanogen bromide method was reacted with ammonium tetrachloroplatinite (II) (NH4)2PtCl4. This conjugate was more suitable for the RAST, than conjugates of HSA and the platinum salt prepared in solution and then linked to the activated Sepharose, showing better sensitivity and giving lower levels of non‐specific uptake of IgE from sera of non‐exposed subjects with high total levels of IgE, e.g. allergic bronchopulmonary aspergillotics. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：109 / 117

页数：9

共 14 条

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