ELEVATED CORTICOSTERONE LEVELS IN TRANSGENIC MICE EXPRESSING HUMAN OR BOVINE GROWTH-HORMONE GENES

被引：44

作者：

CECIM, M

GHOSH, PK

ESQUIFINO, AI

BEGAN, T

WAGNER, TE

YUN, JS

BARTKE, A

机构：

[1] SO ILLINOIS UNIV,SCH MED,DEPT PHYSIOL,CARBONDALE,IL 62901

[2] UNIV COMPLUTENSE MADRID,FAC MED,DEPT BIOCHEM,MADRID 3,SPAIN

[3] OHIO UNIV,EDISON ANIM BIOTECHNOL CTR,ATHENS,OH 45701

来源：

NEUROENDOCRINOLOGY | 1991年 / 53卷 / 03期

关键词：

CORTICOSTERONE; TRANSGENIC MICE; GROWTH HORMONE; STRESS;

D O I：

10.1159/000125734

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ectopic expression of human or bovine growth hormone (GH) genes in 6 lines of transgenic mice was associated with a significant increase in plasma corticosterone levels. Elevated corticosterone levels were detected in both sexes under basal conditions and after ether stress. The adrenal activity of 3-beta-hydroxysteroid dehydrogenase was measured in two of these lines and was found to be significantly increased in transgenic animals. Plasma corticosterone levels in transgenic mice did not correlate with known differences between the various lines in male and female fertility or in the life span.

引用

页码：313 / 316

页数：4

共 16 条

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