ISOLATION AND CHARACTERIZATION OF PHOSMIDOSINE A NEW ANTIFUNGAL NUCLEOTIDE ANTIBIOTIC

被引：38

作者：

URAMOTO, M

KIM, CJ

KAZUO, SY

KUSAKABE, H

ISONO, K

PHILLIPS, DR

MCCLOSKEY, JA

机构：

[1] INST PHYS & CHEM RES, ANTIBIOT LAB, WAKO, SAITAMA 35101, JAPAN

[2] UNIV UTAH, DEPT BIOCHEM, SALT LAKE CITY, UT 84112 USA

[3] UNIV UTAH, DEPT MED CHEM, SALT LAKE CITY, UT 84112 USA

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 04期

关键词：

D O I：

10.7164/antibiotics.44.375

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new nucleotide antibiotic, phosmidosine was isolated from a culture filtrate of a newly isolated streptomycete identified as Streptomyces sp. RK-16. HRFAB-MS and elemental analysis established the molecular formula of C16H24N7O8P. H-1, C-13 and P-31 NMR indicated the presence of a methyl phosphate group and UV spectra were similar to those of 8-hydroxyadenosine. The antibiotic inhibited spore formation of Botrytis cinerea at the concentration of 0.25-mu-g/ml.

引用

页码：375 / 381

页数：7

共 7 条

[1] RAPID DIFFERENTIATION BETWEEN NOCARDIA + STREPTOMYCES BY PAPER CHROMATOGRAPHY OF WHOLE-CELL HYDROLYSATES [J].