ERYTHROCYTE-MEMBRANE FLUIDITY AND CHANGES IN PLASMA-LIPID COMPOSITION - A POSSIBLE RELATIONSHIP IN CHILDHOOD OBESITY

被引：12

作者：

FERRETTI, G ^{[1
]}

CURATOLA, G ^{[1
]}

BERTOLI, E ^{[1
]}

CATASSI, C ^{[1
]}

GIORGI, PL ^{[1
]}

机构：

[1] FAC MED ANCONA, INST PEDIAT, I-60131 ANCONA, ITALY

来源：

BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY | 1991年 / 46卷 / 01期

关键词：

D O I：

10.1016/0885-4505(91)90044-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have studied plasma lipid patterns and erythrocyte membrane fluidity in 60 obese children and 20 normal children. Plasma levels of total cholesterol and associated lowdensity lipoproteins were significantly increased in 20 obese patients with respect to controls. A significant decrease in membrane fluidity, measured as an increase in the fluorescence polarization value of the probe 1,6-diphenyl-1,3,5-hexatriene, associated with an increase in the cholesterol/protein ratio has been shown in obese patients. The study of the correlation between erythrocyte membrane fluidity and plasma cholesterol has indicated that significant changes in fluidity and membrane lipid composition also occur in erythrocytes of obese patients with normal plasma lipid levels. These findings confirm that the erythrocyte membrane responds very early to modifications of plasma lipoproteins and suggest that in childhood obesity a modified transfer of cholesterol from plasma to erythrocyte membrane may take place. © 1991.

引用

页码：1 / 9

页数：9

共 30 条

[1] INTERCORRELATIONS AMONG PLASMA HIGH-DENSITY LIPOPROTEIN, OBESITY AND TRIGLYCERIDES IN A NORMAL POPULATION [J].