ALKALOIDS FROM LEAVES AND ROOT BARK OF ERVATAMIA-HIRTA

被引：66

作者：

CLIVIO, P ^{[1
]}

RICHARD, B ^{[1
]}

DEVERRE, JR ^{[1
]}

SEVENET, T ^{[1
]}

ZECHES, M ^{[1
]}

LEMENOLIVER, L ^{[1
]}

机构：

[1] CNRS, INST CHIM SUBST NAT, F-91198 GIF SUR YVETTE, FRANCE

来源：

PHYTOCHEMISTRY | 1991年 / 30卷 / 11期

关键词：

ERVATAMIA-HIRTA; APOCYNACEAE; LEAVES; ROOT BARK; INDOLE ALKALOIDS; H-1 AND C-13 NMR;

D O I：

10.1016/0031-9422(91)80111-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During chemical investigation of the leaves and root bark of Ervatamia hirta, 33 alkaloids were isolated. Seven are new: six are the 'monomeric' alkaloids (E) 16-epi-normacusine B, (E) 16-epi-affinisine, O-acetyl-16-epi-affinisine, affinisine-N(4)-oxide, dehydro-16-epi-affinisine, norfluorocurarine-N(4)-oxide, and the seventh is the bisindole 16-decarbomethoxyvoacamine-pseudoindoxyl. The known alkaloids are: (E) 16-epi-isositsirikine, beta-yohimbine, yohimbine, 19,20-dehydro-beta-yohimbine, beta-yohimbine-pseudoindoxyl, isositsirikine, 19,20-dihydroisositsirikine, beta-yohimbine-oxindole, normacusine B, affinisine, vobasine, dregamine, tabernaemontanine, norfluorocurarine, 12-hydroxynorfluorocurarine, apparicine, 3,14-dihydroellipticine, antirhine, voacristine, ibogaine, iboxygaine, iboxygaine-hydroxyindolenine, iboluteine, 4',17,(17-beta)-dihydrotchibangensine, 16-decarbomethoxyvoacamine and 19,20-dihydro-16-decarbomethoxyvoacamine. Structural elucidation of the new alkaloids is based on spectral data and chemical correlations.

引用

页码：3785 / 3792

页数：8

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