NOVEL SYNTHESES OF GABAPENTIN VIA ADDITION OF HYDROCYANIC ACID TO CYCLOHEXYLIDENEMALONATE OR CYANO(CYCLOHEXYLIDENE)ACETATE

被引：23

作者：

GRIFFITHS, G ^{[1
]}

METTLER, H ^{[1
]}

MILLS, LS ^{[1
]}

PREVIDOLI, F ^{[1
]}

机构：

[1] LONZA AG,FORSCH ABT SPARTE ORGAN CHEM,CH-3930 VISP,SWITZERLAND

来源：

HELVETICA CHIMICA ACTA | 1991年 / 74卷 / 02期

关键词：

D O I：

10.1002/hlca.19910740208

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several synthetic pathways to the anticonvulsivum gabapentin (1-(aminomethyl)cyclohexaneacetic acid) have been investigated. Advantages and drawbacks of the different routes are discussed, and the most economical and technically most feasible synthesis is pointed out.

引用

页码：309 / 314

页数：6

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