THE BASIS OF THE HISTAMINE ASSAY IN SKIN

被引：4

作者：

BYROM, H ^{[1
]}

CLARK, M ^{[1
]}

WHITE, V ^{[1
]}

VERE, DW ^{[1
]}

机构：

[1] UNIV LONDON LONDON HOSP, COLL MED, DEPT CLIN PHARMACOL & THERAPEUT, TURNER ST, LONDON E1 2AD, ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 32卷 / 03期

关键词：

HISTAMINE; SKIN; ASSAY;

D O I：

10.1111/j.1365-2125.1991.tb03913.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The assay of wheal response to histamine injected sub-epidermally has been reviewed. Several discrepant claims were found in earlier work. 2 The saline control injection may evoke a wheal, which if present should be allowed for in the assay procedure. 3 There was no evidence for a limb dominance effect. 4 Using a 3.26 mM (1 mg ml-1) standard solution of histamine acid phosphate (1.18 mM as free base) and 0.1 ml injections, the straight central portion of the assay curve was found to be between 0.3 and 2.3 x 10(-3) mM, as free base, with an ED50 of about 0.018 mM histamine base.

引用

页码：367 / 370

页数：4

共 11 条

[1] SOME ASPECTS OF THE ACTION OF HISTAMINE ANTAGONISTS [J].