ENHANCED SYNTHESIS OF CYSTEINYL LEUKOTRIENES IN JUVENILE RHEUMATOID-ARTHRITIS

被引：21

作者：

FAULER, J ^{[1
]}

THON, A ^{[1
]}

TSIKAS, D ^{[1
]}

VONDERHARDT, H ^{[1
]}

FROLICH, JC ^{[1
]}

机构：

[1] HANNOVER MED SCH, DEPT PEDIAT, D-30623 HANNOVER, GERMANY

来源：

ARTHRITIS AND RHEUMATISM | 1994年 / 37卷 / 01期

关键词：

D O I：

10.1002/art.1780370114

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Endogenous synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis (JRA) was investigated. Methods. Cysteinyl leukotriene synthesis was assessed by measuring the excretion of leukotriene E(4) (LTE(4)) in urine by radioimmunoassay. The identity of urinary LTE(4) was investigated by gas chromatography-mass spectrometry (GC-MS), and 2,3-dinor-thromboxane B-2 was measured with GC-MS. Results. Excretion of LTE(4) into urine was significantly (P < 0.05) enhanced in children with JRA compared with that in healthy children (n = 10). Aspirin, in a dosage of 2.5 gm/day, had no effect on urinary LTE(4) levels, but it reduced urinary 2,3-dinorthromboxane B-2 levels by more than 85% in healthy adults. There was a positive correlation between LTE(4) excretion and the number of affected joints. Conclusion. This study demonstrates a markedly enhanced cysteinyl leukotriene synthesis and a positive correlation between LTE(4) excretion and the number of affected joints in children with JRA.

引用

页码：93 / 97

页数：5

共 18 条

[1] A STUDY OF CLASSIFICATION CRITERIA FOR A DIAGNOSIS OF JUVENILE RHEUMATOID-ARTHRITIS [J].

CASSIDY, JT ;

LEVINSON, JE ;

BASS, JC ;

BAUM, J ;

BREWER, EJ ;

FINK, CW ;

HANSON, V ;

JACOBS, JC ;

MASI, AT ;

SCHALLER, JG ;

FRIES, JF ;

MCSHANE, D ;

YOUNG, D .

ARTHRITIS AND RHEUMATISM, 1986, 29 (02) :274-281

[2] ENHANCED CAPACITY FOR RELEASE OF LEUCOTRIENE-B4 BY NEUTROPHILS IN RHEUMATOID-ARTHRITIS [J].

ELMGREEN, J ;

NIELSEN, OH ;

AHNFELTRONNE, I .

ANNALS OF THE RHEUMATIC DISEASES, 1987, 46 (07) :501-505

[3] ENHANCED URINARY-EXCRETION OF LEUKOTRIENE-E4 BY PATIENTS WITH MULTIPLE TRAUMA WITH OR WITHOUT ADULT RESPIRATORY-DISTRESS SYNDROME [J].

FAULER, J ;

TSIKAS, D ;

HOLCH, M ;

SEEKAMP, A ;

NERLICH, ML ;

STURM, J ;

FROLICH, JC .

CLINICAL SCIENCE, 1991, 80 (05) :497-504

[4] HUMAN NEUTROPHIL CHEMOTACTIC AND DEGRANULATING ACTIVITIES OF LEUKOTRIENE-B5 (LTB5) DERIVED FROM EICOSAPENTAENOIC ACID [J].

GOLDMAN, DW ;

PICKETT, WC ;

GOETZL, EJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 117 (01) :282-288

[5]

HACKSHAW KV, 1992, J RHEUMATOL, V19, P252

[6]

HAMMARSTROM S, 1985, MOL CELL BIOCHEM, V69, P7

[7]

HERLIN T, 1992, 12TH P EUR C RHEUM

[8] METABOLISM OF CYSTEINYL LEUKOTRIENES IN MONKEY AND MAN [J].

HUBER, M ;

MULLER, J ;

LEIER, I ;

JEDLITSCHKY, G ;

BALL, HA ;

MOORE, KP ;

TAYLOR, GW ;

WILLIAMS, R ;

KEPPLER, D .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 194 (01) :309-315

[9]

KEPPLER D, 1989, ADV ENZYME REGUL, V28, P307, DOI 10.1016/0065-2571(89)90078-2

[10]

KOSHIHARA Y, 1988, PROSTAG LEUKOTR ESS, V32, P113

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