INTEGRATED OPTICAL-DIFFERENCE INTERFEROMETER AS BIOCHEMICAL SENSOR

被引：28

作者：

STAMM, C ^{[1
]}

LUKOSZ, W ^{[1
]}

机构：

[1] SWISS FED INST TECHNOL,OPT LAB,CH-8093 ZURICH,SWITZERLAND

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 1994年 / 18卷 / 1-3期

关键词：

D O I：

10.1016/0925-4005(94)87081-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An integrated optical difference (or polarimetric) interferometer has been used for real-time monitoring of protein adsorption on an SiO2-TiO2 waveguide surface. The different adsorption behaviours of avidin, NeutrAvidin and streptavidin are studied. The affinity reactions between the different immobilized (adsorbed) avidin molecules as receptors and biotinylated bovine serum albumin (BSA) molecules as ligands are also monitored. Subnanomolar concentrations of biotinylated BSA can be selectively detected. Lower limits for the adsorption and reaction constants are determined.

引用

页码：183 / 187

页数：5

共 5 条

[1]

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[3]

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[5] INTEGRATED OPTICAL-DIFFERENCE INTERFEROMETER AS REFRACTOMETER AND CHEMICAL SENSOR [J].

STAMM, C ;

LUKOSZ, W .

SENSORS AND ACTUATORS B-CHEMICAL, 1993, 11 (1-3) :177-181

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