INFREQUENT CHROMOSOME ALLELE LOSS IN FIBROLAMELLAR CARCINOMA

被引：15

作者：

DING, SF

DELHANTY, JDA

BOWLES, L

DOOLEY, JS

WOOD, CB

HABIB, NA

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT SURG,DU CANE RD,LONDON W12 0NN,ENGLAND

[2] UNIV LONDON,ROYAL FREE HOSP,SCH MED,DEPT SURG,LONDON NW3 2QG,ENGLAND

[3] UNIV LONDON,ROYAL FREE HOSP,SCH MED,DEPT MED,LONDON NW3 2QG,ENGLAND

[4] UNIV LONDON UNIV COLL,DEPT GENET & BIOMETRY,LONDON NW1 2HE,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1993年 / 67卷 / 02期

关键词：

D O I：

10.1038/bjc.1993.47

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As yet, there is no reported study of chromosome allele loss in fibrolamellar carcinoma (FLC), a distinct, rare variant of hepatocellular carcinoma (HCC). We searched for evidence of allele loss in FLC using 18 DNA probes for 10 chromosomes and compared the pattern of loss with our series of HCC. Two of the probes, lambdaMS32 (1q42-43) and cMS621 (5p) showed allele losses in one tumour, while other probes showed no loss. The frequency of allele loss in FLC was much lower than in HCC, which may be associated with their different prognoses.

引用

页码：244 / 246

页数：3

共 18 条

[1] GROWTH-FACTORS AND CANCER [J].