CD1 RECOGNITION BY MOUSE NK1(+) T-LYMPHOCYTES

被引：820

作者：

BENDELAC, A ^{[2
]}

LANTZ, O

QUIMBY, ME

YEWDELL, JW

BENNINK, JR

BRUTKIEWICZ, RR

机构：

[1] NIAID, CELLULAR & MOLEC IMMUNOL LAB, BETHESDA, MD 20892 USA

[2] PRINCETON UNIV, DEPT MOLEC BIOL, PRINCETON, NJ 08544 USA

[3] NIAID, VIRAL DIS LAB, BETHESDA, MD 20892 USA

来源：

SCIENCE | 1995年 / 268卷 / 5212期

关键词：

D O I：

10.1126/science.7538697

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of CD1-specific T cells selected during T cell development, or whether their recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of alpha beta thymocytes with a unique phenotype was found to be CD1-specific. This particular subset, and its human counterpart, provide evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells.

引用

页码：863 / 865

页数：3

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