SEX-DIFFERENCES IN THE BEHAVIORAL-RESPONSE TO PERSISTENT PAIN IN RATS

被引：100

作者：

ALOISI, AM

ALBONETTI, ME

CARLI, G

机构：

[1] Istituto di Fisiologia Umana, Università degli Studi di Siena, I-53100 Siena

来源：

NEUROSCIENCE LETTERS | 1994年 / 179卷 / 1-2期

关键词：

SEX DIFFERENCE; FORMALIN TEST; NOVELTY; PAIN;

D O I：

10.1016/0304-3940(94)90939-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The behavioural response to formalin-induced persistent pain was examined in male and female rats both unfamiliar and familiar with the test apparatus. Rats were subcutaneously injected with 50 mu l of formalin (10%) in the hindpaw and placed in the test cage (60 min). Licking and Flexing duration and Paw-Jerk frequency were recorded. Licking and Flexing lasted longer in females than males, while Paw-Jerk occurred in both sexes with comparable frequencies. Flexing and Paw-Jerk were lower in animals unfamiliar with the test apparatus. Therefore, behavioural responses to pain appeared to be affected by sex and familiarization with the experimental setting in different and independent ways.

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页码：79 / 82

页数：4

相关论文

共 23 条

[1] BRAIN-STEM LESIONS DISSOCIATE NEURAL MECHANISMS OF MORPHINE ANALGESIA IN DIFFERENT KINDS OF PAIN [J].

ABBOTT, FV ;

MELZACK, R .

BRAIN RESEARCH, 1982, 251 (01) :149-155

[2] MORPHINE ANALGESIA AND TOLERANCE IN THE TAIL-FLICK AND FORMALIN TESTS - DOSE-RESPONSE RELATIONSHIPS [J].

ABBOTT, FV ;

MELZACK, R ;

LEBER, BF .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1982, 17 (06) :1213-1219

[3] THE STRESS OF A NOVEL ENVIRONMENT REDUCES FORMALIN PAIN - POSSIBLE ROLE OF SEROTONIN [J].

ABBOTT, FV ;

FRANKLIN, KBJ ;

CONNELL, B .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 126 (1-2) :141-144

[4] SEX-DEPENDENT EFFECTS OF RESTRAINT ON NOCICEPTION AND PITUITARY-ADRENAL HORMONES IN THE RAT [J].

ALOISI, AM ;

STEENBERGEN, HL ;

VANDEPOLL, NE ;

FARABOLLINI, F .

PHYSIOLOGY & BEHAVIOR, 1994, 55 (05) :789-793

[5] RODENT SEX-DIFFERENCES IN EMOTIONAL AND RELATED BEHAVIOR [J].

ARCHER, J .

BEHAVIORAL BIOLOGY, 1975, 14 (04) :451-479

[6] STRESS HORMONES - THEIR INTERACTION AND REGULATION [J].

AXELROD, J ;

REISINE, TD .

SCIENCE, 1984, 224 (4648) :452-459

[7] SEX-RELATED DIFFERENCES IN THE EFFECTS OF MORPHINE AND STRESS ON VISCERAL PAIN [J].

BAAMONDE, AI ;

HIDALGO, A ;

ANDRESTRELLES, F .

NEUROPHARMACOLOGY, 1989, 28 (09) :967-970

[8] HORMONAL DETERMINANTS OF SEX DIFFERENCES IN AVOIDANCE BEHAVIOR AND REACTIVITY TO ELECTRIC SHOCK IN RAT [J].

BEATTY, WW ;

BEATTY, PA .

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1970, 73 (03) :446-&

[9] ESTROGEN-RECEPTOR IN RAT-BRAIN - PRESENCE IN THE HIPPOCAMPAL-FORMATION [J].

BETTINI, E ;

POLLIO, G ;

SANTAGATI, S ;

MAGGI, A .

NEUROENDOCRINOLOGY, 1992, 56 (04) :502-508

[10] UNILATERAL ANALGESIA PRODUCED BY INTRAVENTRICULAR MORPHINE [J].

COHEN, SR ;

ABBOTT, FV ;

MELZACK, R .

BRAIN RESEARCH, 1984, 303 (02) :277-287