FAMILIAL 21/21 TRANSLOCATION

被引：6

作者：

LAWTON, SB

STODDARD, GR

SEELY, JR

机构：

[1] Department of Pediatrics Children's Memorial Hospital, University of Oklahoma Medical Center, Oklahoma City, OK

[2] Clinical Research Center, Children's MemorialHospital, University of Oklahoma Medical Center, Oklahoma City, OK

来源：

JOURNAL OF PEDIATRICS | 1969年 / 74卷 / 02期

关键词：

D O I：

10.1016/S0022-3476(69)80083-1

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A family is presented in which 8 consecutive pregnancies produced 3 children affected with Down's syndrome and 5 spontaneous abortions. The 3 siblings were demonstrated to have translocation trisomy-21 of the G/G type; analysis of maternal cells revealed a modal chromosome number of 45 and presence of a G/G translocation carrier state. Morphologic detail does not at present provide differentiation between chromosomes of the G-group; however, statistical analysis demonstrates the probability that this represents a 21/21 translocation; only 2 similar cases were found in the literature. © 1969 The C. V. Mosby Company.

引用

页码：305 / &

共 11 条

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