BIOTRANSFORMATION OF HIGHLY SUBSTITUTED ENT-KAUR-16-ENES BY RHIZOPUS-NIGRICANS

被引：11

作者：

GARCIAGRANADOS, A

MARTINEZ, A

ONORATO, ME

RUIZ, ML

SANCHEZ, JM

ARIAS, JM

机构：

[1] UNIV GRANADA, SERV TECN, E-18071 GRANADA, SPAIN

[2] UNIV GRANADA, FAC CIENCIAS, DEPT MICROBIOL, E-18071 GRANADA, SPAIN

来源：

PHYTOCHEMISTRY | 1990年 / 29卷 / 01期

关键词：

biotransformation; fungus; metabolites; Rhizopus nigricans; structural determination; tetrasubstituted ent-kaur-16-enes;

D O I：

10.1016/0031-9422(90)89024-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The behaviour of Rhizopus nigricans in the biotransformation of 3,7,15,18-tetrasubstituted ent-kaur-16-enes has been studied. Incubation of ent-18-acetoxy-3β-hydroxy-7α,15β-isopropylidenedioxykaur -16-ene by R. nigricans for 48 hr yielded mainly a 13-hydroxyl derivative. Incubation for eight days produced ent-16β,17-epoxidation, hydroxylation at C-12 and C-13, and ent-16α,1 7-dihydroxylation. Occasionally R. nigricans deacetylated and hydrolysed the isopropilidene group. The structure of the metabolites were determined by both spectroscopic (mainly by monodimensional and bidimensional NMR) and chemical means. © 1990.

引用

页码：121 / 126

页数：6

共 25 条

[1] HOMONUCLEAR BROAD-BAND DECOUPLING AND 2-DIMENSIONAL J-RESOLVED NMR-SPECTROSCOPY [J].