ANTIMICROBIAL ACTIONS OF CALCIUM-BINDING LEUKOCYTE L1 PROTEIN, CALPROTECTIN

被引：446

作者：

STEINBAKK, M

NAESSANDRESEN, CF

LINGAAS, E

DALE, I

BRANDTZAEG, P

FAGERHOL, MK

机构：

[1] ULLEVAL HOSP,DEPT MICROBIOL,N-0407 OSLO,NORWAY

[2] NATL HOSP NORWAY,DEPT MICROBIOL,OSLO 1,NORWAY

[3] NATL HOSP NORWAY,DEPT IMMUNOHISTOCHEM & IMMUNOPATHOL,OSLO 1,NORWAY

[4] ULLEVAL HOSP,BLOOD BANK,N-0407 OSLO,NORWAY

[5] ULLEVAL HOSP,DEPT CLIN PHYSIOL,N-0407 OSLO,NORWAY

来源：

LANCET | 1990年 / 336卷 / 8718期

关键词：

D O I：

10.1016/0140-6736(90)93237-J

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The calcium binding L1 protein was found to inhibit growth of blood culture isolates of Candidaspp and cerebrospinal fluid isolates of Cryptococcus neoformans. Minimum inhibitory concentrations (MIC) were 4-128 mg/l, and concentrations 2-4 times the MIC were fungicidal. Blood culture isolates of Escherichia coli, Klebsiella spp, Staphylococcus aureus, and Staphylococcus epidermidis had MIC values of 64-256 mg/l. Antibacterial activity was strongly influenced by the nature of the culture medium. In view of the biological activity of L1, the name calprotectin is proposed to describe this antimicrobial protein with calcium binding properties. © 1990.

引用

收藏

页码：763 / 765

页数：3

相关论文

共 18 条

[1] THE LEUKOCYTE L1-PROTEIN - IDENTITY WITH THE CYSTIC-FIBROSIS ANTIGEN AND THE CALCIUM-BINDING MRP-8 AND MRP-14 MACROPHAGE COMPONENTS [J].

ANDERSSON, KB ;

SLETTEN, K ;

BERNTZEN, HB ;

DALE, I ;

BRANDTZAEG, P ;

JELLUM, E ;

FAGERHOL, MK .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1988, 28 (02) :241-245

[2] DISTRIBUTION OF A FORMALIN-RESISTANT MYELOMONOCYTIC ANTIGEN (L1) IN HUMAN-TISSUES .2. NORMAL AND ABERRANT OCCURRENCE IN VARIOUS EPITHELIA [J].

BRANDTZAEG, P ;

DALE, I ;

FAGERHOL, MK .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1987, 87 (06) :700-707

[3] DISTRIBUTION OF A NEW MYELOMONOCYTIC ANTIGEN (L1) IN HUMAN PERIPHERAL-BLOOD LEUKOCYTES - IMMUNOFLUORESCENCE AND IMMUNOPEROXIDASE STAINING FEATURES IN COMPARISON WITH LYSOZYME AND LACTOFERRIN [J].

DALE, I ;

BRANDTZAEG, P ;

FAGERHOL, MK ;

SCOTT, H .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1985, 84 (01) :24-34

[4] PURIFICATION AND PARTIAL CHARACTERIZATION OF A HIGHLY IMMUNOGENIC HUMAN-LEUKOCYTE PROTEIN, THE L1-ANTIGEN [J].

DALE, I ;

FAGERHOL, MK ;

NAESGAARD, I .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 134 (01) :1-6

[5] IONOMYCIN-REGULATED PHOSPHORYLATION OF THE MYELOID CALCIUM-BINDING PROTEIN P14 [J].

EDGEWORTH, J ;

FREEMONT, P ;

HOGG, N .

NATURE, 1989, 342 (6246) :189-192

[6] RAPID METHOD FOR THE ISOLATION OF NEUTROPHILS IN HIGH-YIELD WITHOUT THE USE OF DEXTRAN OR DENSITY GRADIENT POLYMERS [J].

EGGLETON, P ;

GARGAN, R ;

FISHER, D .

JOURNAL OF IMMUNOLOGICAL METHODS, 1989, 121 (01) :105-113

[7]

FAGERHOL MK, 1980, SCAND J HAEMATOL, V24, P393

[8] SEQUENCE IDENTITY [J].

FREEMONT, P ;

HOGG, N ;

EDGEWORTH, J .

NATURE, 1989, 339 (6225) :516-516

[9] MONOCLONAL-ANTIBODY 5.5 REACTS WITH P8,14, A MYELOID MOLECULE ASSOCIATED WITH SOME VASCULAR ENDOTHELIUM [J].

HOGG, N ;

ALLEN, C ;

EDGEWORTH, J .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (06) :1053-1061

[10] CALGRANULIN EXPRESSION IN INFLAMMATORY DERMATOSES [J].

KELLY, SE ;

JONES, DB ;

FLEMING, S .

JOURNAL OF PATHOLOGY, 1989, 159 (01) :17-21