FUSION OF DISUBSTITUTED BENZENES

被引：35

作者：

MARTIN, E ^{[1
]}

WELLS, JE ^{[1
]}

YALKOWSKY, SH ^{[1
]}

机构：

[1] UPJOHN CO,PHARM RES UNIT,KALAMAZOO,MI 49001

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 05期

关键词：

Benzenes; disubstituted—entropy of fusion; melting point; heat of fusion; structure—activity relationships; Entropy of fusion—disubstituted benzenes; independent of hydrogen bonding; shape; size; dipole moment of rigid molecules; structure‐activity relationships; Melting point—analysis; disubstituted benzenes;

D O I：

10.1002/jps.2600680512

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The entropy of fusion of 84 disubstituted benzenes was essentially constant and independent of the participation of the compounds in intramolecular or intermolecular hydrogen bonding. It was also independent of the shapes, sizes, and dipole moments of the rigid molecules studied. While the entropy of fusion was independent of these parameters, the melting point and the heat of fusion showed a direct dependence on molecular properties. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：565 / 568

页数：4

共 13 条

[1] THE ENTROPY OF FUSION OF LONG CHAIN HYDROCARBONS
ARANOW, RH
WITTEN, L
ANDREWS, DH
[J]. JOURNAL OF PHYSICAL CHEMISTRY, 1958, 62 (07) : 812 - 816
[2] A CORRELATION OF ENTROPY OF FUSION OF MOLECULAR CRYSTALS WITH MOLECULAR STRUCTURE
BONDI, A
[J]. CHEMICAL REVIEWS, 1967, 67 (05) : 565 - +
[3] BONDI A, 1968, PHYSICAL PROPERTIES
[4] ADDITIVE-CONSTITUTIVE CHARACTER OF PARTITION COEFFICIENTS
HANSCH, C
NIKAITANI, D
LEO, A
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (20) : 3090 - +
[5] LUTTRINGHAUS A, 1949, BER, V82, P376
[6] McClellan A., 1960, HYDROGEN BOND
[7] MCCLELLAN AL, 1963, TABLES DIPOLE MOMENT
[8] NYS GG, 1974, EUR J MED CHEM, V9, P361
[9] The form of space fulfillment of organic molecules as a deciding factor in the size of the molar melting heat.
Pirsch, J
[J]. BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1937, 70 : 12 - 23
[10] PIRSCH J, 1956, MIKROCHIM ACTA, V1, P992

← 1 2 →