POSTOPERATIVE ADJUVANT IMMUNOCHEMOTHERAPY WITH MITOMYCIN-C, TEGAFUR, PSK AND OR OK-432 FOR GASTRIC-CANCER, WITH SPECIAL REFERENCE TO THE CHANGE IN STIMULATION INDEX AFTER GASTRECTOMY

被引：18

作者：

HATTORI, T

NAKAJIMA, T

NAKAZATO, H

TANABE, T

KIKUCHI, K

ABE, O

KONDO, T

TAGUCHI, T

KOMI, N

SUGIMACHI, K

TOMINAGA, S

TSURU, S

INOKUCHI, K

机构：

[1] Shakai-Hoken Nakabaru Hospital, Fukuoka, 811-22, Mitarai, Shime-machi, Kasuya-gun

[2] The Division of Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research

[3] The Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Aichi

[4] The Second Department of Surgery, Hokkaido University, School of Medicine, Hokkaido

[5] Sendai National Hospital, Sendai

[6] The Department of Surgery, Keio University School of Medicine, Keio

[7] Tokai Central Hospital, Tokai

[8] The Department of Surgery, Research Institute for Microbial Diseases, Osaka University, Osaka

[9] The Department of Surgery, University of Tokushima School of Medicine, Tokushima

[10] The Second Department of Surgery, Kyushu University Faculty of Medicine, Kyushu

[11] The Division of Epidemiology, Aichi Cancer Center Research Institute, Aichi

[12] The Department of Bacteriology, National Defense Medical College

[13] Saga Prefectural Hospital Kouseikan, Saga

来源：

JAPANESE JOURNAL OF SURGERY | 1990年 / 20卷 / 02期

关键词：

gastric cancer; mitomycin-C; OK-432; PSK; tegafur;

D O I：

10.1007/BF02470759

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

In order to evaluate the efficacy of combined immunochemotherapy with mitomycin-C, tegafur, PSK and/or OK-432 as an adjunct for curatively resected gastric cancer, a prospective randomized controlled study using the envelope method was performed, in which 266 institutions from around Japan participated. The 3 year survival rates for all cases, and for ps(+)·n(+) cases, were insignificantly higher in the immunochemotherapy groups receiving PSK and/or OK-432 than in the control group. However, because 28.2 per cent of the cases were excluded from the final statistical analyses, the results of this study may have questionable statistical credibility. Changes in the stimulation index (SI) suggest that the administration of PSK may result in an inhibition of the immunosuppressive activity of cancer patients. The high SI group showed a significantly higher 4 year survival rate than the low SI group. © 1990 The Japan Surgical Society.

引用

页码：127 / 136

页数：10

共 27 条

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