SELECTIVE ATTENUATION OF COCAINE-INDUCED STEREOTYPED BEHAVIOR BY OXYTOCIN - PUTATIVE ROLE OF BASAL FOREBRAIN TARGET SITES

被引：63

作者：

SARNYAI, Z ^{[1
]}

BABARCZY, E ^{[1
]}

KRIVAN, M ^{[1
]}

SZABO, G ^{[1
]}

KOVACS, GL ^{[1
]}

BARTH, T ^{[1
]}

TELEGDY, G ^{[1
]}

机构：

[1] CZECHOSLOVAK ACAD SCI, INST ORGAN CHEM & BIOCHEM, CS-11142 PRAGUE 1, CZECHOSLOVAKIA

来源：

NEUROPEPTIDES | 1991年 / 19卷 / 01期

关键词：

D O I：

10.1016/0143-4179(91)90073-R

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of oxytocin (OXT), arginine- and lysine-vasopressin (AVP and LVP) and an OXT-receptor antagonist on cocaine-induced sniffing behaviour were investigated in rats. OXT, but not AVP or LVP injected subcutaneously (s.c.) attenuated cocaine-induced sniffing. The effect of OXT (s.c.) was inhibited by an OXT-receptor antagonist administered intracerebroventricularly (i.c.v.).l.c.v. administration of different doses of OXT in nanogram quantities caused a dose-dependent attentuation of cocaine-induced sniffing. Local cerebral microinjection of OXT into the accumbens nucleus and olfactory tubercle but not into the olfactory nucleus, central amygdaloid nucleus or caudate nucleus, inhibited the cocaine-induced sniffing behaviour. These results demonstrate that OXT selectively attenuates the cocaine-induced stereotyped behaviour through basal forebrain target sites.

引用

页码：51 / 56

页数：6

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