A CONVENIENT SYNTHESIS OF 7-ALLYL-8-SUBSTITUTED GUANOSINES

被引：7

作者：

COME, J ^{[1
]}

BURR, L ^{[1
]}

CHEN, R ^{[1
]}

机构：

[1] RW JOHNSON PHARMACEUT RES INST,DIV MED CHEM,RARITAN,NJ 08869

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(00)93470-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and useful synthesis of 7-allyl-8-substituted guanosine derivatives has been achieved using a Claisen rearrangement as the key step.

引用

页码：4823 / 4826

页数：4

共 11 条

[1] THE HETERO-COPE REARRANGEMENT IN ORGANIC-SYNTHESIS [J].

BLECHERT, S .

SYNTHESIS-STUTTGART, 1989, (02) :71-82

[2] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME 8-SUBSTITUTED SELENOGUANOSINE CYCLIC 3',5'-PHOSPHATES AND RELATED COMPOUNDS [J].

CHU, SH ;

SHIUE, CY ;

CHU, MY .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (06) :559-564

[3]

GOODMAN MG, 1985, J IMMUNOL, V135, P3284

[4]

GOODMAN MG, 1986, J IMMUNOL, V136, P3335

[5] SYNTHESIS AND BROAD-SPECTRUM ANTIVIRAL ACTIVITY OF 7,8-DIHYDRO-7-METHYL-8-THIOXOGUANOSINE [J].

HENRY, EM ;

KINI, GD ;

LARSON, SB ;

ROBINS, RK ;

ALAGHAMANDAN, HA ;

SMEE, DF .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (08) :2127-2130

[6] PURINE NUCLEOSIDES .7. DIRECT BROMINATION OF ADENOSINE DEOXYADENOSINE GUANOSINE + RELATED PURINE NUCLEOSIDES [J].

HOLMES, RE ;

ROBINS, RK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (06) :1242-&

[7] 8-SUBSTITUTED GUANOSINE AND 2'-DEOXYGUANOSINE DERIVATIVES AS POTENTIAL INDUCERS OF THE DIFFERENTIATION OF FRIEND-ERYTHROLEUKEMIA CELLS [J].

LIN, TS ;

CHENG, JC ;

ISHIGURO, K ;

SARTORELLI, AC .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (09) :1194-1198

[8] CATALYSIS OF THE COPE AND CLAISEN REARRANGEMENTS [J].

LUTZ, RP .

CHEMICAL REVIEWS, 1984, 84 (03) :205-247

[9]

MIZUTANI M, 1983, J ORG CHEM, V24, P455

[10] PURINE NUCLEOSIDES .27. SYNTHESIS OF I- AND 7-METHYL-8-OXOGUANOSINE AND RELATED NUCLEOSIDES . USE OF N-AMINO GROUP AS A SELECTIVE BLOCKING AGENT IN NUCLEOSIDE SYNTHESIS [J].

RIZKALLA, BH ;

ROBINS, RK ;

BROOM, AD .

BIOCHIMICA ET BIOPHYSICA ACTA, 1969, 195 (02) :285-&

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