ATP AND GTP AS ALTERNATIVE ENERGY-SOURCES FOR VINBLASTINE TRANSPORT BY P-170 IN KB-V1 PLASMA-MEMBRANE VESICLES

被引：30

作者：

LELONG, IH

PADMANABHAN, R

LOVELACE, E

PASTAN, I

GOTTESMAN, MM

机构：

[1] NCI,CELL BIOL LAB,BLDG 37,ROOM 1B22,BETHESDA,MD 20892

[2] NCI,MOLEC BIOL LAB,BETHESDA,MD 20892

来源：

FEBS LETTERS | 1992年 / 304卷 / 2-3期

关键词：

MULTIDRUG RESISTANCE; UPTAKE; VESICLE;

D O I：

10.1016/0014-5793(92)80632-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purified plasma membrane vesicles isolated from multidrug-resistant human KB-V1 cells accumulate [H-3]vinblastine in an energy-dependent manner. The accumulation of [H-3]vinblastine in the presence of ATP is a saturable process. ATP can be replaced by other purine nucleotide triphosphates, of which GTP is the most efficient.

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页码：256 / 260

页数：5

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