A METHOD OF INCREASING THE SENSITIVITY FOR LASER-DESORPTION IN AN ION-TRAP MASS-SPECTROMETER

被引：21

作者：

EIDEN, GC ^{[1
]}

CISPER, ME ^{[1
]}

ALEXANDER, ML ^{[1
]}

HEMBERGER, PH ^{[1
]}

NOGAR, NS ^{[1
]}

机构：

[1] LOS ALAMOS NATL LAB,DIV CHEM & LASER SCI,CLS-1 MS-G740,LOS ALAMOS,NM 87545

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 1993年 / 4卷 / 09期

关键词：

D O I：

10.1016/1044-0305(93)80048-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Laser desorption in an ion trap mass spectrometer shows significant promise for both qualitative and trace analysis. In this work, we explore various combinations of time-varying DC and radiofrequency (RF) fields in order to optimize laser-generated signals. By judicious choice of timing between the laser desorption pulse and the rise in the applied RF trapping potential, we observed over an order of magnitude enhancement in the trapped ion signal. This new method for laser desorption has enabled us to observe mass spectra of many compounds (e.g., pyrene, dichlorobenzene, and ferrocene) that are barely detectable using previous laser desorption methods. Effects of laser timing and the magnitude of the steady-state RF potential are discussed.

引用

页码：706 / 709

页数：4

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