DIASTEREOSELECTIVE HYDROGENATION AND KINETIC RESOLUTION OF IMINES USING RHODIUM DIPHOSPHINE CATALYZED HYDROGENATION

被引：25

作者：

LENSINK, C

DEVRIES, JG

机构：

[1] DSM Research, 6160 MD Geleen

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(00)82341-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Kinetic resolution of racemic alpha-methylbenzyl amine can be achieved with 98% e.e. of the remaining amine at 70% conversion using the Rhodium/2S,4S-BDPP catalyzed asymmetric hydrogenation of imines. The same catalyst will hydrogenate optically pure alpha-methylbenzyl amines with a diastereoselectivity of up to 333:1.

引用

页码：215 / 222

页数：8

共 22 条

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