TOTAL SYNTHESIS OF THE BETA-METHOXYACRYLATE-BASED FUNGICIDE MYXOTHIAZOL

被引：32

作者：

MARTIN, BJ

CLOUGH, JM

PATTENDEN, G

WALDRON, IR

机构：

[1] UNIV NOTTINGHAM, DEPT CHEM, NOTTINGHAM NG7 2RD, ENGLAND

[2] ICI PLC, AGROCHEM, JEALOTTS HILL RES STN, BRACKNELL RG12 6EY, BERKS, ENGLAND

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(00)60700-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A total synthesis of the novel antifungal substance myxothiazol 1 isolated from the myxobacterium Myxococcus fulvus is described. The synthesis is based on elaboration of the S-E,E-diene thioamide 15 and the 2R S, 3S R amide aldehyde 25 as key intermediates, followed by conversion of 15 into the bis-thiazole 19 and a final Wittig coupling reaction between 2 S and the salt 20 c leading to 7S,18S R, 19R S myxothiazol.

引用

页码：5151 / 5154

页数：4

共 23 条

[1]

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