EXPRESSION OF BCL-2 INHIBITS NECROTIC NEURAL CELL-DEATH

被引：208

作者：

KANE, DJ

ORD, T

ANTON, R

BREDESEN, DE

机构：

[1] UNIV CALIF LOS ANGELES,CEL,BRAIN RES INST,DEPT NEUROL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,DEPT NEUROL,LOS ANGELES,CA 90024

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1995年 / 40卷 / 02期

关键词：

APOPTOSIS; AURINTRICARBOXYLIC ACID; BUTHIONINE SULFOXIMINE; GLUTATHIONE; GT1-7;

D O I：

10.1002/jnr.490400216

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis of neural cells induced by glutathione depletion. This finding demonstrates that bcl-2 does not inhibit the cellular death program directly; rather, bcl-2 modulates a cellular process that leads to apoptosis under some conditions but necrosis under others. (C) 1995 Wiley-Liss, Inc.

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页码：269 / 275

页数：7

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