DETECTION OF NEO-ANTIGENIC SITES ON THE D-DIMER PEPTIDE ISOLATED FROM PLASMIN DIGESTED CROSS LINKED FIBRIN

被引：11

作者：

LEEOWN, V

GORDON, YB

CHARD, T

机构：

[1] LONDON HOSP,COLL MED,LONDON EC1A 7BE,ENGLAND

[2] ST BARTHOLOMEWS HOSP,COLL MED,DEPT OBSTET GYNAECOL & REPROD PHYSL,LONDON EC1A 7BE,ENGLAND

来源：

THROMBOSIS RESEARCH | 1979年 / 14卷 / 01期

关键词：

D O I：

10.1016/0049-3848(79)90026-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cross linked fibrin was subjected to plasmin digestion and the degradation peptide D-dimer isolated by gel filtration and ion-exchange chromatograph. Antisera to D-dimer were raised in rabbits. Using these antisera and a tracer preparation of [125I]D-dimer a radioimmunoassay was developed. One of the rabbit antisera was shown to contain antibodies directed against neoantigenic sites on the D-dimer. © 1979.

引用

页码：77 / 84

页数：8

共 18 条

[1]

CHEN JP, 1974, FED PROC, V33, P218

[2]

EDGINGTON TS, 1975, J BIOL CHEM, V250, P3393

[3] CHARACTERIZATION OF COLLAGEN PEPTIDES BY SODIUM DODECYLSULFATE-POLYACRYLAMIDE ELECTROPHORESIS [J].