PRENATAL MATERNAL PHENOBARBITAL ALTERS PLASMA CONCENTRATIONS OF CORTICOSTERONE IN DEVELOPING OFFSPRING

被引：9

作者：

MIDDAUGH, LD ^{[1
]}

BOGGAN, WO ^{[1
]}

WILSONBURROWS, C ^{[1
]}

ZEMP, JW ^{[1
]}

机构：

[1] MED UNIV S CAROLINA, DEPT PSYCHIAT & BEHAV SCI, CHARLESTON, SC 29401 USA

来源：

LIFE SCIENCES | 1979年 / 24卷 / 11期

关键词：

D O I：

10.1016/0024-3205(79)90318-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Offspring of mice injected daily with phenobarbital for the last 1/3 of pregnancy had elevated concentrations of corticosterone on the day of birth and reduced concentrations 21 days after birth. The high concentration at birth suggests a compensatory increase in fetal corticosterone due to reductions in maternal corticosterone. The lower concentration of corticosterone at 21 days of age is compatible with reports on the effects of neonatal injections of corticosterone on plasma concentrations of the glucocorticoid in young rats.

引用

页码：999 / 1002

页数：4

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