SYNTHETIC ANTHRACYCLINES - TOTAL SYNTHESIS OF D-RING PYRIDINE AND PYRAZINE ANALOGS OF 11-DEOXYDAUNOMYCIN

被引：18

作者：

KITA, Y

KIRIHARA, M

FUJII, Y

OKUNAKA, R

AKAI, S

MAEDA, H

TAMURA, Y

SHIMOOKA, K

OHISHI, H

ISHIDA, T

机构：

[1] PFIZER PHARMACEUT INC LTD, CTR NEW PROD DEV, TAKETOYO, AICHI 47023, JAPAN

[2] OSAKA UNIV PHARMACEUT SCI, OSAKA 580, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 04期

关键词：

11-DEOXYDAUNOMYCIN ANALOG; HETEROANTHRACYCLINE; AZATETRAHYDRONAPHTHACENE; CYCLOADDITION; ANTITUMOR AGENT;

D O I：

10.1248/cpb.39.857

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Treatment of sodium salts generated from tetrahydrohomophthalic anhydrides (6a, b) with 5,8-dihydro-5,8-dioxoquinoline (9) gave cycloadducts (7 and 8), regioselectively. These adducts were converted to the D-ring pyridine analogue (21) of 11-deoxydaunomycin. The D-ring pyrazine analogue (27) of 11-deoxydaunomycin was also prepared by a similar method.

引用

页码：857 / 864

页数：8

共 46 条

[1] SYNTHESIS AND PRELIMINARY ANTI-TUMOR EVALUATION OF 5-IMINODOXORUBICIN [J].