ABUSE POTENTIAL AND PHARMACOLOGICAL COMPARISON OF TRAMADOL AND MORPHINE

被引：186

作者：

PRESTON, KL ^{[1
]}

JASINSKI, DR ^{[1
]}

TESTA, M ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21224

来源：

DRUG AND ALCOHOL DEPENDENCE | 1991年 / 27卷 / 01期

关键词：

TRAMADOL; MORPHINE; ABUSE LIABILITY; HUMAN SUBJECTS;

D O I：

10.1016/0376-8716(91)90081-9

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The purpose of the study was to assess the abuse potential of the opioid analgesic tramadol. Tramadol (75, 150 and 300 mg), morphine (15 and 30 mg) and placebo were tested intramuscularly in volunteer non-dependent opiate abusers. Subjective, behavioral and miotic changes were assessed prior to dosing and intermittently for 12 h after drug administration. Morphine produced typical subjective effects, opiate identifications and miosis. Tramadol 75 and 150 mg were not different from placebo. Although tramadol 300 mg was identified as an opiate, it produced no other morphine-like effects. These findings suggest that tramadol has a low abuse potential by the parenteral route.

引用

页码：7 / 17

页数：11

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