HIGH AND PROLONGED PULMONARY TISSUE CONCENTRATIONS OF AZITHROMYCIN FOLLOWING A SINGLE ORAL DOSE

被引:51
作者
MORRIS, DL
DESOUZA, A
JONES, JA
MORGAN, WE
机构
[1] ST GEORGE HOSP,DEPT SURG,KOGARAH,NSW 2217,AUSTRALIA
[2] NOTTINGHAM CITY HOSP,DEPT SURG,NOTTINGHAM NG5 1PB,ENGLAND
关键词
D O I
10.1007/BF01975842
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Antibiotic concentrations in pulmonary tissue samples and plasma were studied in this open investigation. Twenty-nine patients scheduled for elective pulmonary surgery received a single oral dose of 500 mg azithromycin 24, 72, 96 or 120 h prior to the operation; two patients received 250 mg b.i.d. Blood samples were taken before and at the time of resection, and tissue was obtained during surgery. Plasma and tissue concentrations of azithromycin were measured by high performance liquid chromatography (HPLC) and a microbiological bioassay. Only one patient had a detectable plasma concentration of azithromycin (0.13-mu-g/ml), measured 24 h post-dose by HPLC. However, high and sustained levels were found in lung tissue: mean concentrations measured by HPLC were 3.10-mu-g/g (SD +/- 2.17), 2.55-mu-g/g (SD +/- 1.36), 3.94-mu-g/g (SD +/- 2.40) and 3.13-mu-g/g (SD +/- 0.50) at 24, 72, 96 and 120 h, respectively. Bioassay results were similar to those for the HPLC assay. In summary, azithromycin levels in pulmonary tissue remained close to 3-mu-g/g for up to 5 days after a single oral 500 mg dose, in contrast to plasma levels which were much lower. The lung concentrations found are inhibitory for many sensitive respiratory pathogens and short-course azithromycin therapy is therefore a possibility.
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页码:859 / 861
页数:3
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共 6 条
  • [1] BALDWIN DR, 1990, EUR RESPIR J, V3, P886
  • [2] SYNTHESIS, INVITRO AND INVIVO ACTIVITY OF NOVEL 9-DEOXO-9A-AZA-9A-HOMOERYTHROMYCIN A DERIVATIVES - A NEW CLASS OF MACROLIDE ANTIBIOTICS, THE AZALIDES
    BRIGHT, GM
    NAGEL, AA
    BORDNER, J
    DESAI, KA
    DIBRINO, JN
    NOWAKOWSKA, J
    VINCENT, L
    WATROUS, RM
    SCIAVOLINO, FC
    ENGLISH, AR
    RETSEMA, JA
    ANDERSON, MR
    BRENNAN, LA
    BOROVOY, RJ
    CIMOCHOWSKI, CR
    FAIELLA, JA
    GIRARD, AE
    GIRARD, D
    HERBERT, C
    MANOUSOS, M
    MASON, R
    [J]. JOURNAL OF ANTIBIOTICS, 1988, 41 (08) : 1029 - 1047
  • [3] THE PHARMACOKINETICS OF AZITHROMYCIN IN HUMAN SERUM AND TISSUES
    FOULDS, G
    SHEPARD, RM
    JOHNSON, RB
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 25 : 73 - 82
  • [4] COMPARATIVE INVITRO ACTIVITIES OF NEW 14-MEMBERED, 15-MEMBERED, AND 16-MEMBERED MACROLIDES
    HARDY, DJ
    HENSEY, DM
    BEYER, JM
    VOJTKO, C
    MCDONALD, EJ
    FERNANDES, PB
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (11) : 1710 - 1719
  • [5] COMPARATIVE-STUDIES OF AZITHROMYCIN IN SKIN AND SOFT-TISSUE INFECTIONS AND SEXUALLY-TRANSMITTED INFECTIONS BY NEISSERIA AND CHLAMYDIA SPECIES
    LASSUS, A
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 25 : 115 - 121
  • [6] COMPARISON OF AZITHROMYCIN AND ERYTHROMYCIN IN THE TREATMENT OF ATYPICAL PNEUMONIAS
    SCHONWALD, S
    GUNJACA, M
    KOLACNYBABIC, L
    CAR, V
    GOSEV, M
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 25 : 123 - 126