2 TYPES OF LINKAGE BETWEEN CODON USAGE AND GENE-EXPRESSION LEVELS

被引：19

作者：

NAKAMURA, T

SUYAMA, A

WADA, A

机构：

[1] UNIV TOKYO,FAC SCI,DEPT PHYS,BUNKYO KU,TOKYO 113,JAPAN

[2] TECH UNIV NAGAOKA,NIIGATA 94021,JAPAN

来源：

FEBS LETTERS | 1991年 / 289卷 / 01期

关键词：

CODON USAGE; GENE EXPRESSION; 3RD LETTER USAGE; (G+C)-CONTENT; TRANSFER RNA CONTENT; NEUTRAL THEORY;

D O I：

10.1016/0014-5793(91)80923-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relation between codon usage and gene-expression levels is an intensively investigated and discussed topic in the field of molecular evolution. We statistically analyzed 25 Escherichia coli gene sequences by a new classification of synonymous codons and found that (i) there are two distinct types of linkage between codon usage and gene-expression levels in E. coli, and (ii) one of the two kinds of codon preferences (the codon preference concerned with interaction of GC/AT choice at three codon positions) is observed significantly in weakly expressed genes.

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页码：123 / 125

页数：3

相关论文

共 12 条

[1] CODON PREFERENCES IN FREE-LIVING MICROORGANISMS [J].

ANDERSSON, SGE ;

KURLAND, CG .

MICROBIOLOGICAL REVIEWS, 1990, 54 (02) :198-210

[2] CODON USAGE AND GENOME COMPOSITION [J].

BERNARDI, G ;

BERNARDI, G .

JOURNAL OF MOLECULAR EVOLUTION, 1985, 22 (04) :363-365

[3] COEVOLUTION OF CODON USAGE AND TRANSFER-RNA ABUNDANCE [J].

BULMER, M .

NATURE, 1987, 325 (6106) :728-730

[4] PREFERENTIAL CODON USAGE IN PROKARYOTIC GENES - THE OPTIMAL CODON ANTICODON INTERACTION ENERGY AND THE SELECTIVE CODON USAGE IN EFFICIENTLY EXPRESSED GENES [J].

GROSJEAN, H ;

FIERS, W .

GENE, 1982, 18 (03) :199-209

[5]

IKEMURA T, 1985, MOL BIOL EVOL, V2, P13

[6] POSSIBILITY OF EXTENSIVE NEUTRAL EVOLUTION UNDER STABILIZING SELECTION WITH SPECIAL REFERENCE TO NON-RANDOM USAGE OF SYNONYMOUS CODONS [J].

KIMURA, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (09) :5773-5777

[7] STRATEGIES FOR EFFICIENCY AND ACCURACY IN GENE-EXPRESSION [J].

KURLAND, CG .

TRENDS IN BIOCHEMICAL SCIENCES, 1987, 12 (04) :126-128

[8] AN EVOLUTIONARY PERSPECTIVE ON SYNONYMOUS CODON USAGE IN UNICELLULAR ORGANISMS [J].

SHARP, PM ;

LI, WH .

JOURNAL OF MOLECULAR EVOLUTION, 1986, 24 (1-2) :28-38

[9] 3RD LETTERS IN CODONS COUNTERBALANCE THE (G+C)-CONTENT OF THEIR 1ST AND 2ND LETTERS [J].

WADA, A ;

SUYAMA, A .

FEBS LETTERS, 1985, 188 (02) :291-294

[10] LOCAL STABILITY OF DNA AND RNA SECONDARY STRUCTURE AND ITS RELATION TO BIOLOGICAL FUNCTIONS [J].

WADA, A ;

SUYAMA, A .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1986, 47 (02) :113-157