HOW DOES P21 RAS TRANSFORM CELLS

被引：79

作者：

MARSHALL, CJ

机构：

来源：

TRENDS IN GENETICS | 1991年 / 7卷 / 03期

关键词：

D O I：

10.1016/0168-9525(91)90063-V

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Oncogenic forms of p21ras are found in a wide range of human tumours. However, the mechanism by which p21ras transforms remains obscure. Genetic evidence has identified a domain of p21ras that is involved with interaction with an effector molecule required for transformation. Two proteins, GAP and the tumour suppressor NF1, interact with p21ras in this region but it is an unresolved puzzle whether either of these is the effector. After interaction with an effector, two downstream events-activation of protein kinase C and another pathway-are necessary for induction of DNA synthesis by oncogenic p21ras; however, morphological transformation does not require activation of protein kinase C.

引用

收藏

页码：91 / 95

页数：5

相关论文

共 43 条

[1] THE NF1 LOCUS ENCODES A PROTEIN FUNCTIONALLY RELATED TO MAMMALIAN GAP AND YEAST IRA PROTEINS [J].

BALLESTER, R ;

MARCHUK, D ;

BOGUSKI, M ;

SAULINO, A ;

LETCHER, R ;

WIGLER, M ;

COLLINS, F .

CELL, 1990, 63 (04) :851-859

[2] MICROINJECTION OF THE RAS ONCOGENE PROTEIN INTO PC12 CELLS INDUCES MORPHOLOGICAL-DIFFERENTIATION [J].

BARSAGI, D ;

FERAMISCO, JR .

CELL, 1985, 42 (03) :841-848

[3]

BOS JL, 1989, CANCER RES, V49, P4682

[4] STIMULATION OF P21RAS UPON T-CELL ACTIVATION [J].

DOWNWARD, J ;

GRAVES, JD ;

WARNE, PH ;

RAYTER, S ;

CANTRELL, DA .

NATURE, 1990, 346 (6286) :719-723

[5] A GENETIC MODEL FOR COLORECTAL TUMORIGENESIS [J].

FEARON, ER ;

VOGELSTEIN, B .

CELL, 1990, 61 (05) :759-767

[6] INHIBITION OF NIH-3T3 CELL-PROLIFERATION BY A MUTANT RAS PROTEIN WITH PREFERENTIAL AFFINITY FOR GDP [J].

FEIG, LA ;

COOPER, GM .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (08) :3235-3243

[7] Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product [J].

Frech, M ;

John, J ;

Pizon, V ;

Chardin, P ;

Tavitian, A ;

Clark, R ;

Mccormick, F ;

Wittinghofer, A .

SCIENCE, 1990, 249 (4965) :169-171

[8] ANTIBODY TO PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE INHIBITS ONCOGENE-INDUCED MITOGENESIS [J].

FUKAMI, K ;

MATSUOKA, K ;

NAKANISHI, O ;

YAMAKAWA, A ;

KAWAI, S ;

TAKENAWA, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) :9057-9061

[9] RAS-INDUCED C-FOS EXPRESSION AND PROLIFERATION IN LIVING RAT FIBROBLASTS INVOLVES C-KINASE ACTIVATION AND THE SERUM RESPONSE ELEMENT PATHWAY [J].

GAUTHIERROUVIERE, C ;

FERNANDEZ, A ;

LAMB, NJC .

EMBO JOURNAL, 1990, 9 (01) :171-180

[10] XENOPUS OOCYTE GERMINAL-VESICLE BREAKDOWN INDUCED BY [VAL12]RAS IS INHIBITED BY A CYTOSOL-LOCALIZED RAS MUTANT [J].

GIBBS, JB ;

SCHABER, MD ;

SCHOFIELD, TL ;

SCOLNICK, EM ;

SIGAL, IS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (17) :6630-6634

← 1 2 3 4 5 →