STATE OF STUPOR FROM VALPROIC ACID DURING CHRONIC TREATMENT - CASE-REPORT

被引：3

作者：

GENTILE, S ^{[1
]}

BUFFA, C ^{[1
]}

RAVETTI, C ^{[1
]}

SACERDOTE, I ^{[1
]}

机构：

[1] OSPED GIOVANNI BOSCO,DIV NEUROL,I-10154 TURIN,ITALY

来源：

ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1991年 / 12卷 / 02期

关键词：

VALPROIC ACID; HYPERAMMONEMIA; ENCEPHALOPATHY; EPILEPSY;

D O I：

10.1007/BF02337037

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe the case of a 26 years old woman in chronic therapy with phenobarbital,, carbamazepine, valproic acid (VPA) and clonazepam who showed a hyperammonemic encephalophaty after an increase in dosage of VPA. Similar cases have been reported, but with acute-subacute onset and no correlation with the plasma levels of VPA. Our case suggests the possibility that this toxic effect occurs during chronic treatment too, when the dosage of VPA is increased.

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页码：215 / 217

页数：3

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