C-ERBB-2 ONCOGENE EXPRESSION IN HEPATOCELLULAR-CARCINOMA AND CHOLANGIOCARCINOMA

被引：43

作者：

COLLIER, JD

GUO, K

MATHEW, J

MAY, FEB

BENNETT, MK

CORBETT, IP

BASSENDINE, MF

BURT, AD

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT MED,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

[2] UNIV NEWCASTLE UPON TYNE,DEPT PATHOL,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

[3] FREEMAN RD HOSP,DEPT PATHOL,NEWCASTLE TYNE NE7 7DN,TYNE & WEAR,ENGLAND

来源：

JOURNAL OF HEPATOLOGY | 1992年 / 14卷 / 2-3期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0168-8278(92)90186-S

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The c-erbB-2 proto-oncogene encodes a transmembrane protein which is homologous to the epidermal growth factor receptor. This protein can be localized immunohistochemically in formalin-fixed paraffin-embedded material using a monoclonal antibody NCL-CB11; positive membrane staining correlates with gene amplification and protein overexpression in breast cancer. Using this technique we have shown that only 2/26 (8%) of hepatocellular carcinomas, 0/10 (0%) of cholangiocarcinomas and 0/2 (0%) hepatoblastomas overexpressed c-erbB-2 as evidenced by membrane staining. Moreover c-erbB-2 mRNA was not detected in seven hepatocellular carcinomas examined by Northern blot analysis. c-erbB-2 overexpression is, therefore, unlikely to be contributing to the malignant phenotype in hepatocellular carcinoma and cholangiocarcinoma.

引用

页码：377 / 380

页数：4

共 10 条

[1] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].