HAS IPRINDOLE AN ALPHA-ADRENERGIC ACTIVITY

被引：2

作者：

GANRY, H

BOURIN, M

机构：

[1] FAC MED NANTES,GIS MEDICAMENT,F-44035 NANTES,FRANCE

[2] FAC MED NANTES,DEPT PHARMACOL,NANTES,FRANCE

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1993年 / 17卷 / 03期

关键词：

ACUTE ADMINISTRATION; ALPHA1; ACTIVITY; ALPHA2; BEHAVIORAL TESTS; IPRINDOLE;

D O I：

10.1016/0278-5846(93)90077-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1- Acute administration of iprindole potentiated the toxicity of 1-norepinephrine and increased the intensity of oxotremorine-induced tremors. 2- On the forced swimming test combination iprindole with imipramine reduced the duration of immobility. 3- The action of yohimbine on the locomotor activity was antagonized by a pre-injection of iprindole. 4- Iprindole increased and prolonged exophtalmia and toss of righting reflex induced by xylazine. 5- All these results seems indicate that iprindole has an indirect alpha1 and alpha2 adrenergic activity.

引用

页码：435 / 451

页数：17

共 45 条

[1] DOPAMINE AND NORADRENALINE RECEPTOR STIMULATION - REVERSAL OF RESERPINE-INDUCED SUPPRESSION OF MOTOR ACTIVITY [J].