MAPPING OF THE PULMONARY SURFACTANT SP5 (SFTP2) LOCUS TO 8P21 AND CHARACTERIZATION OF A MICROSATELLITE REPEAT MARKER THAT SHOWS FREQUENT LOSS OF HETEROZYGOSITY IN HUMAN CARCINOMAS

被引：15

作者：

WOOD, S

YAREMKO, ML

SCHERTZER, M

KELEMEN, PR

MINNA, J

WESTBROOK, CA

机构：

[1] UNIV CHICAGO,DEPT PATHOL,CHICAGO,IL

[2] UNIV CHICAGO,DEPT SURG,CHICAGO,IL

[3] UNIV CHICAGO,DEPT MED,CHICAGO,IL

[4] UNIV TEXAS,SW MED CTR,SIMMONS CANC CTR,DALLAS,TX

来源：

GENOMICS | 1994年 / 24卷 / 03期

关键词：

D O I：

10.1006/geno.1994.1673

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have identified 4 cosmids at the SFTP2 locus by cDNA hybridization. SFTP2 was mapped using a polymorphic CA repeat and localized to 8p21 by FISH. Allele loss in carcinomas was detected using this PCR marker. Among 11 lung and colon tumors, 6 of 9 informative cases exhibited allelic loss. (C) 1994 Academic Press, Inc.

引用

页码：597 / 600

页数：4

共 22 条

[1]

EMI M, 1992, CANCER RES, V52, P5368

[2] ISOLATION AND MAPPING OF 88 NEW RFLP MARKERS ON HUMAN CHROMOSOME-8 [J].