EPIDURAL-ANESTHESIA IN AN IN-VITRO FERTILIZATION AND EMBRYO-TRANSFER PROGRAM

被引:17
作者
BOTTA, G
DANGELO, A
DARI, G
MERLINO, G
CHAPMAN, M
GRUDZINSKAS, G
机构
[1] Ecocenter and Fertility Center, Clinica 'C. G. Ruesch', Napoli, 80122
[2] Department of Obstetrics and Gynaecology, University of New South Wales, Sydney
[3] Academic Unit of Obstetrics and Gynaecology, London Hospital Medical College, London
关键词
ANESTHESIA; IVF-ET; EPIDURAL ANESTHESIA; TRANSVAGINAL OOCYTE RETRIEVAL;
D O I
10.1007/BF02211796
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Objectives: To investigate the potential advantages of epidural anesthesia in an in vitro fertilization and embryo transfer program. Study Design: Between January 1991 and December 1992, 148 infertile patients underwent transvaginal ultrasound guided oocyte retrieval. A total of 44 patients (group A) had 50 retrievals under epidural anesthesia, and 104 patients (group B, control group) 112 retrievals under intravenous sedation (propofol) with mask-assisted ventilation (nitrous oxide). Results: In group A satisfactory anesthesia was achieved in 49 of the 50 cases (98%); one patient required additional intravenous administration of propofol owing to extreme anxiety. No complications were observed. Adversely, in group B nausea was observed in 16 cases (14%) and nausea and vomiting in 7 cases (6%). In group A the fertilization, cleavage and pregnancy rates were 67.2%, 92% and 20% respectively, while in group B the rates were 69.3%, 93% and 19.6% respectively; the differences are not statistically significant. Conclusions: Epidural anesthesia is an effective method for transvaginal oocyte retrieval but does not improve the treatment outcome as compared to an intravenous sedation with mask-assisted ventilation using propofol and nitrous oxide.
引用
收藏
页码:187 / 190
页数:4
相关论文
共 11 条
[1]  
Boyers S.P., Lavy G., Russell J.B., DeCherney A.H., A paired analysis of in vitro fertilization and cleavage rates of firstversus last-recovered preovulatory human oocytes exposed to varying intervals of 100% CO<sub>2</sub> pneumoperitoneum and general anesthesia, Fertil Steril, 48, (1987)
[2]  
Hayes M.F., Sacco A.G., Savoy-Moore R.T., Magyar D.M., Endler G.C., Moghissi K.S., Effect of general anesthesia on fertilization and cleavage of human oocytes in vitro, Fertil Steril, 48, (1987)
[3]  
Lehtinen A-M, Laatikainen T., Koskimies A.I., Hovorka J.E., Modifying effects of epidural analgesia or general anesthesia on the stress hormone response to laparoscopy for in vitro fertilization, J In Vitro Fertil Embryo Transfer, 4, (1987)
[4]  
Degueldre M., Puisasant F., Camus M., Toberg A., Thi H.P., Melot C., Leroy F., Effects on carbon dioxide insufflation at laparoscopy on the gas phase in oocyte recovery fluids, J In Vitro Fertil Embryo Transfer, 1, (1984)
[5]  
Palot M., Harika J., Pigeon F., Lamiable D., Rendoing J., Propofol in general anesthesia for IVF (by transvaginal and transuretral route)-follicular fluid concentration and cleavage rates, Anesthesiology, 69, (1988)
[6]  
Shoeffler P.F., Levron J.C., Jany L., Brenas F.J., Pouly J.L., Follicular concentration of fentanyl during laparoscopy for oocyte retrieval-correlation with in vitro fertilization results, Anesthesiology, 69, (1988)
[7]  
Endler G.C., Stout M., Magyar D.M., Hayes M.F., Moghissi K.S., Sacco A.G., Follicular fluid concentrations of thiopental and thiamylal during laparoscopy for oocyte retrieval, Fertil Steril, 48, (1987)
[8]  
Palot M., Harika G., Visseaux H., Guillet H., Pigeon F., Leon A., Rendoing J., Faut-il utiliser le protoxide d'azote au cours de l'anesthesie generale pour prelevement d'ovocytes en vue de la Fivete?, Ann Fr Anesth Reanim, 8, (1989)
[9]  
Chetkowski R.J., Nass T.E., Isoflurane inhibits early mouse embryo development in vitro, Fertil Steril, 49, (1988)
[10]  
Warren R.J., Shaw B., Steinkampf M.P., Effects of nitrous oxide on preimplantation mouse embryo cleavage and development, Biol Reprod, 43, (1990)