OBSERVATIONS ON EPIDERMAL DIFFERENTIATION IN FETAL RAT

被引：81

作者：

BONNEVILLE, MA

机构：

[1] Dermatologic Genetics Laboratory, New England Center Hospital, Boston, Massachusetts

[2] The Biological Laboratories, Harvard University, Cambridge, Massachusetts, 02138

来源：

AMERICAN JOURNAL OF ANATOMY | 1968年 / 123卷 / 01期

关键词：

D O I：

10.1002/aja.1001230107

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Study of fetal rat epidermis has revealed the presence of a single layer of nonkeratinizing cells, the periderm, that covers the free surface of the skin during embryonic life. The periderm resembles structurally the epithelium lining the amniotic cavity, and the two are believed to be similar in function and embryonic origin. Observations of keratinization have shown that keratohyalin granules formed initially during fetal life may differ in structure from those formed during later fetal life and in the adult. Those formed first contain lipidlike globules embedded in a dense granular matrix. Those formed next contain dense patches of finely granular material embedded in a less dense matrix. Granules formed late in fetal life have a homogeneous structure and resemble those of adult skin. As in adult epidermis, tonofibrils, abundant in epidermal cells prior to cornification, probably contribute to formation of the keratohyalin granules. Also, as in adult tissue, ribosomes lie close to the surfaces of developing keratohyalin granules and seem to be involved in their formation. Copyright © 1968 Wiley‐Liss, Inc.

引用

页码：147 / +

页数：1

共 35 条

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[2]

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[3]

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[4]

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