OCTAMER OF CORE HISTONES IN SOLUTION - CENTRAL ROLE OF THE H3.H4 TETRAMER IN THE SELF-ASSEMBLY

被引：127

作者：

RUIZCARRILLO, A

JORCANO, JL

机构：

[1] Max-Planck-Institut für Molekulare Genetik

来源：

BIOCHEMISTRY | 1979年 / 18卷 / 05期

关键词：

D O I：

10.1021/bi00572a004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The association of histones H2A, H2B, H3, and H4 in solution has been studied. In 2 M NaCl and at neutral pH they can assemble in a complex in which each histone is present in equimolar amounts. The complex has a weight average molecular weight of 98 000 (±3700) and a sedimentation coefficient (s020, w) of 4.8. The value of the weight average molecular weight and the histone stoichiometry indicate that the complex is an octamer. The pairs of histones H2A, H2B and H3, H4 studied separately under identical. © 1979, American Chemical Society. All rights reserved.

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页码：760 / 768

页数：9

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