RELEASE OF CALCITONIN GENE-RELATED PEPTIDE INDUCED BY CAPSAICIN IN THE VASCULARLY PERFUSED RAT STOMACH

被引：116

作者：

HOLZER, P

PESKAR, BM

PESKAR, BA

AMANN, R

机构：

[1] RUHR UNIV BOCHUM,DEPT EXPTL CLIN MED,W-4630 BOCHUM,GERMANY

[2] RUHR UNIV BOCHUM,DEPT PHARMACOL & TOXICOL,W-4630 BOCHUM,GERMANY

来源：

NEUROSCIENCE LETTERS | 1990年 / 108卷 / 1-2期

关键词：

Calcitonin gene-related peptide; Capsaicin; High-pressure liquid chromatography; Primary afferent neuron; Transmitter release; Vascular bed of the rat stomach;

D O I：

10.1016/0304-3940(90)90730-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been suggested that capsaicin-induced gastric mucosal protection results from the local release of vasodilator peptides such as calcitonin gene-related peptide (CGRP) from afferent nerve endings within the stomach, since CGRP is able to reduce gastric lesion formation. This concept is supported by the present finding that capsaicin (10-5 M), administered to the vascularly perfused stomach of the rat, produces a more than 30-fold rise of the CGRP content of the venous effluent. High-pressure liquid chromatography revealed only one peak of immunoreactivity coeluting with synthetic CGRP. © 1990.

引用

页码：195 / 200

页数：6

共 30 条

[1] EFFECTS OF HCGRP-I AND HCGRP-II ON GASTRIC BLOOD-FLOW AND ACID-SECRETION IN ANESTHETIZED RABBITS [J].