SYNERGISTIC EFFECT OF INTERLEUKIN-1 AND SOLUBLE CD23 ON THE GROWTH OF HUMAN CD4+ BONE MARROW-DERIVED T-CELLS

被引：30

作者：

BERTHO, JM ^{[1
]}

FOURCADE, C ^{[1
]}

DALLOUL, AH ^{[1
]}

DEBRE, P ^{[1
]}

MOSSALAYI, MD ^{[1
]}

机构：

[1] CHU PITIE SALPETRIERE,IMMUNOL LAB,CNRS,URA 186,F-75634 PARIS 13,FRANCE

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 04期

关键词：

D O I：

10.1002/eji.1830210433

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Low-affinity Fc-epsilon-receptor (Fc-epsilon-RII/CD23) is expressed by various human cells and known to be cleaved into soluble fragments (sCD23). Several biological activities were ascribed to these molecules. In this study, we have assessed the effect of recombinant 25-kDa sCD23 (rsCD23) on human bone marrow-derived T cells. Our results show that rsCD23 in synergy with recombinant interleukin 1 enhances mitogenic responsiveness of CD4+ T cells but does not affect CD8+ cell growth. Furthermore, rsCD23 synergizes autologous marrow cells in enhancement of CD4+ cell growth while CD23 monoclonal antibodies decrease accessory cell effect. Together, these data confirm cytokine-like activity of sCD23 on human T cell lineage.

引用

页码：1073 / 1076

页数：4

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