TYROSINE-HYDROXYLASE GENE-EXPRESSION IN HUMAN VENTRAL MESENCEPHALON - DETECTION OF TYROSINE-HYDROXYLASE MESSENGER-RNA IN NEURITES

被引：24

作者：

DUMAS, S

JAVOYAGID, F

HIRSCH, E

AGID, Y

MALLET, J

机构：

[1] CNRS,NEUROBIOL CELLULAIRE LAB,F-91198 GIF SUR YVETTE,FRANCE

[2] HOP LA PITIE SALPETRIERE,MED EXPTL LAB,INSERM,U289,F-75651 PARIS 13,FRANCE

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1990年 / 25卷 / 04期

关键词：

dendrites; Parkinson's disease; TH;

D O I：

10.1002/jnr.490250415

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of both tyrosine hydroxylase (TH) antigen and messenger RNA was investigated in the ventral mesencephalon from human brain using a 35S‐labeled human TH cDNA probe and a polyclonal TH antibody. A hybridization signal was detected not only in the perikaryon but also in the neurites, most probably dendrites, of immunoreactive neurons. In cell bodies, the level of TH mRNA varies, revealing a regional heterogeneity. In the substantia nigra of patients with Parkinson's disease the number of labeled cells was markedly reduced as compared to controls. Copyright © 1990 Wiley‐Liss, Inc.

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页码：569 / 575

页数：7

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