INDUCTION OF COPULATORY-BEHAVIOR IN SEXUALLY INACTIVE RATS BY NALOXONE

被引：172

作者：

GESSA, GL ^{[1
]}

PAGLIETTI, E ^{[1
]}

PELLEGRINIQUARANTOTTI, B ^{[1
]}

机构：

[1] TECNOFARMACI SPA,POMEZIA,ROME,ITALY

来源：

SCIENCE | 1979年 / 204卷 / 4389期

关键词：

D O I：

10.1126/science.432642

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The intraventricular injection of D-alanine-methionine-enkephalinamide (D-Ala2-Met-enkephalinamide), a synthetic analog of Met-enkephalin that is resistant to enzymatic degradation, inhibits copulatory behavior in sexually vigorous male rats in doses which do not influence motor activity or feeding behavior. This effect is prevented by naloxone, a specific inhibitor of opioid receptors. In addition, injections of naloxone induce copulatory behavior in sexually inactive male rats. These results suggest that endorphins play an important role in the regulation of sexual behavior. Copyright © 1979 AAAS.

引用

页码：203 / 204

页数：2

共 16 条

[1]

BIGGIO G, 1977, ADV BIOCH PSYCHOPHAR, V16

[2] ENKEPHALIN PENTAPEPTIDES - REVIEW OF CURRENT EVIDENCE FOR A PHYSIOLOGICAL-ROLE IN VERTEBRATE NEUROTRANSMISSION [J].